Before acting, McCoy-Misick began her career as a model doing fashion shows in churches and high schools in her native Chicago. She made her acting debut as the lead in Reasons, an independent film directed by Monty Ross. She also had the lead role in the film The Players Club, directed and written by Ice Cube.; and has film credits in The Wood, opposite Omar Epps, as well as Love the Way, Rhapsody, All About You, and Go for Broke. In 2003, McCoy starred as Neesee James in the CW sitcom All of Us. She played Robert Sr.'s (Duane Martin) self-absorbed ex-wife and the mother of their 6-year-old son, Bobby, Jr. The series ended in 2007.
In 2005, she launched two fashion lines: Luxe & Romance, a lingerie line that was introduced during New York's Fashion Week, and Xraye, a jeans line for women.
In addition to acting, McCoy has also appeared in several music videos including Tupac Shakur's last video, "Toss It Up", Sisqó's "Incomplete", Lil Jon and Ice Cube's "Roll Call" Video clip, and Ludacris' "Number 1 Spot." McCoy also recorded the single "Would You?" with rapper Benzino.
